
Jose A. Lefran, MD
My Biography
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Professional Background
Professional Background
Dr. Jose A. Lefran is a board-certified cardiologist based in Orlando, FL, with over 25 years of experience. He attended the University of Juarez School of Medicine and completed his internal medicine residency and cardiology fellowship at Seton Hall University. Dr. Lefran has served as Vice Chief of Cardiology at Orlando Health, Dr. P. Phillips Hospital. He is an active clinical researcher, having participated in major pharmaceutical trials for heart attack and heart failure treatments. Dr. Lefran has expertise in nuclear cardiology and maintains board certification in Internal Medicine and Cardiovascular disease from the American Board of Internal Medicine.
Dr. Jose A. Lefran is a board-certified cardiologist based in Orlando, FL, with over 25 years of experience. He attended the University of Juarez School of Medicine and completed his internal medicine residency and cardiology fellowship at Seton Hall University. Dr. Lefran has served as Vice Chief of Cardiology at Orlando Health, Dr. P. Phillips Hospital. He is an active clinical researcher, having participated in major pharmaceutical trials for heart attack and heart failure treatments. Dr. Lefran has expertise in nuclear cardiology and maintains board certification in Internal Medicine and Cardiovascular disease from the American Board of Internal Medicine.
My Locations
Hospital Affiliations
- Orlando Health
- Advent Healthcare
- HCA

Patient Submitted Review
Feb-2025
Very knowledgeable and experienced, Excellent communication skills, Efficient and timely, and Staff was also very friendly and helpful. I would highly recommend him to anyone.
Patient Submitted Review
Feb-2025
Today was my fvery first visit ever to a Cardiologist. I had the pleasure of meeting Dr. LeFran and his team. I left very pleased with everyone. The experience was positive. The care and attention I received from this doctor was amazing.
Patient Submitted Review
Feb-2025
My appointment went great and doctor answered all of my concerns, and also send me for test , and upgraded my medication. He is very professional with a very high level of knowledge of cardiology.
Patient Submitted Review
Jan-2025
Last Friday I had the opportunity to be treated by Dr. José with Jackie. I thank God for having found them and I am sure that they will solve the situation in my heart. My God bless the doctor's knowledge and recommendations, which demonstrate, through the treatment I felt, the human burden of his being. Jackie, I hope the same blessings for you, because your patience in finding me an exam that didn't give me claustrophobia showed me your big heart in the good sense of the word. Thank you Doctor Jose, Claudio N.
Patient Submitted Review
Dec-2024
(Translated by Google) As always, optimal and excellent care, from Dr Lefran and the entire medical team, nurses and secretaries in general. I felt more than satisfied. Happy 🥳 holidays 🍾🎊🎅🏻🎄☃️🎉 (Original) Como siempre una atención óptima y excelente, de parte del Dr Lefran y de todo el equipo médico, enfermeras y secretarias en general . Me sentí más que satisfecha. Felices 🥳 fiestas 🍾🎊🎅🏻🎄☃️🎉
Patient Submitted Review
Dec-2024
Dr. Lefran is a fantastic physician. He is a very personable individual. He is clear in his explanation to his patients and attentively listens to their concerns. I've been going to him since the early 2000's and have always been pleased with him and his staff.
Patient Submitted Review
Dec-2024
Dr LeFran has been my Cardiologist since 2011. He has always given me the best care. He takes time to listen, uses the necessary tests to diagnose and makes good assessments. He doesn’t over react, nor does he ignore important steps necessary to take appropriate measures for situations and circumstances that mandate them. I am thankful that Dr LeFran is my doctor. I trust him.
rater8 Verified Patient
Nov-2024
Dr Lefran is an exceptional doctor. He is attentive and knowledgeable about my condition. He listens to all concerns and responds positively. His plans are clearly explained and answers all questions you have. Dr Lefran makes you comfortable.
rater8 Verified Patient
Nov-2024
I have complete confidence in Dr. Lafran and know that he takes all of my somewhat complicated conditions into consideration when he makes decisions about my ongoing care. I trust him and like him.
Patient Submitted Review
Nov-2024
It is awesome to reunite with Dr. LaFran after 9 years of being away from Orlando. Dr. LaFran cares very much about your health and wellbeing. He spends the time to know you and provide the appropriate health care that you deserve. He listens and addresses all of your concerns. Just an awesome person as well as an awesome physician. I definitely recommend him to my family and friends.
Patient Submitted Review
Nov-2024
Very personable. Dr. LaFran takes the time with you and is very patient in answering all of your questions. All of the other Doctors and Nurses are just as friendly!!
Patient Submitted Review
Oct-2024
From when we walked in to when we meet the doctors and nurses it was like being with friends. Very respectful and knowledgeable. Dr. Lefran was amazing, courteous nice , treated us like people, explained everything , very caring and made us feel so good about our Choice. My hearth is in very good hands. Great people, and the nice lady at the check out she listened to us and did the best she could and more , to accommodate our requests.i would reccomend this practice to anyone i know., Thank you
Patient Submitted Review
Oct-2024
Dr. Lefran is very caring, knowledgeable, and professional. He listens well and explains everything completely. He instills confidence and trust into the patient - doctor relationship.
Patient Submitted Review
Oct-2024
Dr LeFran is the best! I’m so glad Angie is back with him too. They both are a perfect team and a great addition to The cardiovascular Center of Florida!
Patient Submitted Review
Oct-2024
I’m treated like family. All test results are explained in clear, concise, and plain English. So very comfortable being treated by Dr. LeFran and his team.
Patient Submitted Review
Sep-2024
I moved to Florida a few months ago and wanted to establish connections_relationships with New Physicians. Dr. LeFran’s name was among “3” that were recommended. The choice was EASY because he had the Best Credentials, Experience and Highly Recommended By Colleagues and Patients. The timeline to see him was not long; typically standard for a new patient. MY visit was not due to any specific Heart Conditions or Problems; simply due to Preventative Measures and Examinations to ensure HeartHealth is Good! And establish a relationship with him_to have a Good Cardiologist among My Doctors for routine checkups and IF it is necessary. Dr. LeFran suggested certain examinations and tests; and a follow up appointment afterwards. He answered ALL my questions and concerns. Discussed prior medical history to better understand past and present healthcare and conditions. I did not feel RUSHED, nor was he RUSHING to see the Next Patient. Listened intently and showed genuine concern. The Staff Is Very, Very Professional! Whenever interacting on the phone or in-person. I Highly Recommend Dr. LeFran and Staff!
rater8 Verified Patient
Sep-2024
As usual, it's a pleasure to see a Dr that takes his time to listen to his patients, something that is so rare nowadays. He is kind, attentive and shows a legitimate interest!
Patient Submitted Review
Aug-2024
Dr. Lefran has been my cardiologist for more than 10 years, and I always get the same caring and professional care. Just want to express my gratitude and appreciation for your care!
Patient Submitted Review
Aug-2024
(Translated by Google) It was my first consultation with Doctor Lefran, and I rate it as excellent. Face-to-face communication with the patient, good questioning and the simplicity of his person are essential to feel comfortable and trust him as a cardiologist. Thank God for that opportunity. (Original) Fue mi primera consulta con el Doctor Lefran, y la califico como excelente. La comunicación cara a cara con el paciente, un buen interrogatorio y la sencillez de su persona, son esenciales para sentirse cómodo y confiar en él como cardiólogo. Gracias a Dios por esa oportunidad
Patient Submitted Review
Aug-2024
Excellent Genuine Customer Service Dr. Lefran & Staff Will follow Dr. LeFran, Angie PA & Staff to the ends of the Earth Cardiovascular Center of Florida, a wonderful and Magical team. Full Stop!
Patient Submitted Review
Aug-2024
Dr.Jose Lefran is the best Cardiologist in Orlando hands down! He treated me like a family member and gave me the absolute truth and peace of mind. I highly recommend and appreciate Dr.LeFran.🫀
rater8 Verified Patient
Jun-2024
I have the utmost confidence in Dr. LeFran. He’s taking care of me for the past 16 years, I would not have anyone else look after my Cardio condition.
rater8 Verified Patient
May-2024
Dr LeFran has been treating my mother for decades. I take her to her appointments and every time we leave we say how much we appreciate Dr. LeFran. He is kind, thorough, and knowledgeable. A great doctor!!!
rater8 Verified Patient
Apr-2024
Greatly appreciate my cardiologist Dr. Lefran for being very professional, very caring and for taking his time during my visit. Thank you for ordering my tests and knowing all went welll with my results. Feeling amazing knowing that my heart is strong. Highly recommend.
rater8 Verified Patient
Mar-2024
Great examination and very caring individual. Took his time with me explaining EKG results and medications. His PA, Angela is also very nice and helped with scheduling.
rater8 Verified Patient
Feb-2024
Dr. LeFran is always courteous and takes the time to listen to all my concerns and questions. He is thorough and makes sure I am clear on all information.
rater8 Verified Patient
Feb-2024
I’ve been seeing Dr.Lefran for about 7 years. He is professional, kind and has excellent bedside manners. He is gentle with his health lectures but always shows true concern.
Patient Submitted Review
Feb-2024
I have been seeing Dr Lefran for 8 yrs now. He is a great Dr. takes time to make sure you understand what your diagnosis is & the treatment for it. Always has time for you. I have great confidence in him.
Patient Submitted Review
Feb-2024
Dr. LeFran, and his assistant Angela are the best. They listen carefully and are very competent and compassionate. If you are looking for a heart specialist, he is great.
Patient Submitted Review
Jan-2024
I have been going to Dr. Jose LeFran for 24 years. You will not be able to find a more caring and knowledgeable doctor. A friend of mine had a condition that many prestigious doctors in Boston were not able to diagnose. Dr. Lefran found the answer and saved him from what could have killed him eventually without the proper medicine.
rater8 Verified Patient
Jan-2024
Dr. Lefran is an extremely caring doctor. He listens to your questions, and always gives good advice. A friend of mine had a health problem that was never diagnose correctly by many prestigious Boston doctors. Dr. Lefran found the answer and properly treated him.
rater8 Verified Patient
Jan-2024
I’ve been going to him for years and feel confident in my care with him. Not sure if I would be alive today if it wasn’t for the tests that he had me take as previous doctor I believe was not capable
Patient Submitted Review
Jan-2024
Always courteous and professional. I have been a patient of Dr. LeFran for years. He always takes the time to address your concerns, no rushed visits.
Patient Submitted Review
Jan-2024
This was by far the best doctors visit. Dr Lefran took the time to explain what he wanted to do and why the tests he ordered were necessary. He puts you completely at ease.
Patient Submitted Review
Jan-2024
Highly recommend Dr. José Leftan and Team. Dr Lefran is very professional physician and listens to his patients, very caring. I have to say he was able to order few test due some symptoms and thanks to him all my test came back very well and I’m att ease. Thank you Dr. Lefran
Patient Submitted Review
Dec-2023
Dr Lefran is an awesome Physican. He is caring, knowledgeable and compassionate. He does nor rush his patients through. His concern is not just for your heart health but your mental and physical health also.
Patient Submitted Review
Dec-2023
Dr. Lefran is very kind, concerned, and compassionate. I have been his patient at OH and I followed him to Cardio Vascular Center of Florida. The staff are friendly and it is easy to get appointments. I feel very blessed Dr. Lefran pursued my health issues with such detail. Highly recommend!
Patient Submitted Review
Nov-2023
Dr. Lefran has a wonderful staff, kind to everyone checking in or making appointments. Dr.Lefran has the best trait of a doctor-he listens! He was also thorough in his approach, explaining where and why we are navigating in the upcoming tests. He gave this patient a peace of mind. Grateful for his kindness and attentiveness in care.
Patient Submitted Review
Nov-2023
Absolutely excellent. Dr. LeFran, as well as the entire staff of highly qualified doctors and nurses, is patient, thorough, and provides clear and accurate consultation and care.
Patient Submitted Review
Nov-2023
Exceptional doctor with attention to detail one of the most important things I love about this doctor he's on top of all aspects of my medical issues, highly recommend.
Patient Submitted Review
Sep-2023
Dr LeFran has been my cardiologist for many years. He and his staff are the most efficient, caring caregivers I've ever encountered. So much so that I recommend him to anyone that needs a cardiologist including my husband.
Patient Submitted Review
Jul-2023
He is very professional and explains the issues clearly without talking down to you. Makes you feel that he genuinely cares about you. A very good experience all the way through.
Patient Submitted Review
Sep-2022
Dr. Lafran has always had taken the time to actually give me a physical and talk to me about my health, he also talks to my other physicians regularly about my health.
Patient Submitted Review
Oct-2021
1. The check-in was extremely efficient, and the receptionist was affable. 2. The nurse was cordially pleasant with her high level of expertise. The Doctor was affable, capable, knowledgeable, and patient-oriented. Dr. Lefran made a potentially apprehensive exam extremely pleasant. PS The check-out was smooth and the lady was patient attentive with easy scheduling.
Patient Submitted Review
Apr-2021
At 36 years old I was scared with an arrhythmia, Dr Lefron was very professional and had excellent beside manners. Years later and my heart is as healthy as the next.
Patient Submitted Review
Jul-2019
Dr. Lefran is an excellent doctor who goes above and beyond to get to the root of a problem. My fiance lived in Boston and suffered with a problem that none of the doctors found there. It took living in Orlando and going to Dr. Lefran who found the answer. He had Addison's Disease. I could go on and on about how wonderful this doctor is but just mentioned one of his many qualities.
Education & Board Certifications
Medical School
- University of Juarez School of Medicine
Fellowship
- Seton Hall University School of Graduate Medical Education
Internship / Residency
- Seton Hall University School of Graduate Medical Education
Patient Submitted Review
Mar-2025
Dr. Joseph LeFran of the Cardiovascular Institute of Florida is an outstanding doctor. His knowledge and approach will let you be confident in the diagnosis and treatment plan. I respect him highly and trust his opinion to keep me healthy.